|
| lofatdairy wrote:
| Similarly, cell lines are known to have variations and make
| replication difficult, especially after a few passages at the
| lab. FBS also being essential to media but being notoriously
| difficult to standardize makes things even trickier.
| aaron695 wrote:
| [dead]
| superkuh wrote:
| It's even worse than the un-life like conditions of allowed
| animal models leading to bad results.
|
| With the increasing regulatory burden and outright outlawing of
| animal models in scientific research biological studies are
| moving to new far-abstracted models that are much cheaper,
| easier, higher N, and counterintuitively, way, way less
| predictive of the actual results in human bodies. Testing
| 1,000,000 compounds in single cell tests (or just chemical
| binding assays) in a micro-well array has less predictive power
| and useful outcome than testing 10 compounds in monkeys. At least
| when it comes to figuring out which things will work in human
| disease. The giant massively abstracted studies also generate
| false positives that waste time. But they do generate
| publications so they're selected for at the funding level.
|
| That's part of the reason biological research was so much more
| productive per $ input last century.
| klipt wrote:
| > That's part of the reason biological research was so much
| more productive per $ input last century.
|
| Isn't part of it also just that the long hanging fruit has
| already been picked?
| beebmam wrote:
| I don't find this very convincing. Do you have any evidence for
| this claim breaking down all the different costs for the
| research and quantified the change in those costs over time, or
| is this just an apriori argument?
| kanzure wrote:
| What's that old joke about mice benefiting from all the
| research but not humans? Maybe we can switch back to (this time
| voluntary) human experimentation at some point.
| teddyh wrote:
| If human experimentation was that more useful, wouldn't a lot
| more scientific results be available from countries with more
| lax laws against it?
| xwdv wrote:
| Problem is those countries suck at research.
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