[HN Gopher] Do fungi lurking inside cancers speed their growth?
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Do fungi lurking inside cancers speed their growth?
 
Author : LinuxBender
Score  : 49 points
Date   : 2022-10-08 16:09 UTC (6 hours ago)
 
web link (www.nature.com)
w3m dump (www.nature.com)
 
| version_five wrote:
| Sometimes I wonder if we're just giant machines built by
| microorganisms. It would certainly make an interesting story,
| along the idea of a robot discovering they were made by somebody
| else, which I believe has already been explored
 
  | unity1001 wrote:
  | > Sometimes I wonder if we're just giant machines built by
  | microorganisms
  | 
  | I believe that we were well-organized colonies of bacteria was
  | proven long time ago.
  | 
  | We are literally a unified collective of cells.
 
    | astrange wrote:
    | Prokaryotes, not bacteria.
    | 
    | https://en.wikipedia.org/wiki/Two-domain_system
 
      | unity1001 wrote:
      | Evaluates to the same concept of we being collectives.
 
  | foobarbecue wrote:
  | We are all servants of the selfish gene.
 
  | seqizz wrote:
  | Reminded me:
  | 
  | > Animals are something invented by plants to move seeds
  | around. An extremely yang solution to a peculiar problem which
  | they faced. (Terence McKenna)
 
    | adammarples wrote:
    | Animals evolved long before plants. What's crazy is that
    | plants were arguably evolved by fungi using alga to farm
    | sunlight
 
      | 11235813213455 wrote:
      | > Animals evolved long before plants
      | 
      | No
      | 
      | underwater: algae 3500MY vs sponges, worms, shells
      | 800MY-485MY
      | 
      | out of water: plants 470MY vs millipedes, tetrapod
      | 420MY-400MY
 
    | 11235813213455 wrote:
    | a nice example of cross evolution, random mutations of both
    | life forms + natural selection, tasty seeds and animals
    | eating them was a good combo
 
    | redanddead wrote:
    | What about underwater plants? Life started in the water first
    | didn't it?
 
  | TaylorAlexander wrote:
  | I mean it's a matter of perspective but... we are aren't we?
 
    | pmayrgundter wrote:
    | Basically agree.
    | 
    | There is an important part in what is meant by "machine".
    | 
    | Mechanics, strictly speaking, is pervasive in but not
    | sufficient to account for the life process.
    | 
    | There's something else going on that looks like classical
    | teleos and both the cells and the organism have it.
    | 
    | There's interesting work to get teleos out of mechanics in
    | far from equilibrium thermodynamics.. Prigogine, Kauffman,
    | Wolfram, Deacon, England even Dennet.
 
  | ip26 wrote:
  | In a sense that's very true. However the biggest wrinkle is
  | that most of your cells share a single common ancestor cell. If
  | your body is a community of microbes, it's _mostly_ a village
  | of close relatives, not a symbiote like coral.
 
    | jvanderbot wrote:
    | Ah, I heard quite differently when including microbiome.
    | 
    | For example: https://www.bbc.com/news/health-43674270 "More
    | than half your body is not human"
 
      | pmayrgundter wrote:
      | I believe that's incidental. There are abiotic mice which
      | seem basically the same but require smth like 20% more
      | calories in their diet for same metabolic level.
 
  | chiefalchemist wrote:
  | Well, we are biological machines that would not survive without
  | a spectrum of microbes (e.g., gut bacteria). And to your point,
  | kinda, I sometimes wonder if they exist for us, or we exist for
  | them.
 
  | CSSer wrote:
  | I think you're thinking of a Philip K. Dick short story. I'll
  | see if I can find it.
  | 
  | Edit: I was thinking of autofac, which is kind of like what
  | you're describing but arguably it was only a small plot detail.
  | 
  | People get downvoted for the strangest things on here
  | sometimes. In this case it just makes me laugh.
 
    | adhesive_wombat wrote:
    | There's also a short story by Stephen Baxter in _Phase Space_
    | (a very excellent collection) called _Dante Dreams_ where a
    | researcher becomes aware of the dreaming consciousness of her
    | own organelles.
 
    | maxbond wrote:
    | Reminded me of The Electric Ant
    | https://archive.org/details/PhilipK.DickTheElectricAnt
    | 
    | I have a hypothesis that commenters sometime interpret
    | recommendations in this format ("I think you're thinking of
    | X") as being presumptive, because it implies someone made a
    | mistake in their thinking. I'm not trying to say it is or
    | isn't, just that I've seen a pattern of similar posts
    | downvoted, and this is my hypothesis as to why.
 
  | klyrs wrote:
  | > Sometimes I wonder if we're just giant machines built by
  | microorganisms.
  | 
  | Wait 'til you find out that those "microorganisms" are
  | themselves machines...
  | 
  | https://en.wikipedia.org/wiki/Molecular_machine#Biological
 
  | perfecthjrjth wrote:
  | Yes, but with a twist: this giant machine worries about its
  | future, its kids, its wealth, its financial assets.
 
    | ww520 wrote:
    | All those are just for satisfying the urge to reproduce.
 
    | version_five wrote:
    | Or tricked into worrying about that as a control signal to
    | perform its main task in service of its microorganism
    | operators ;)
 
      | hgomersall wrote:
      | Which is all subservient to its actual main task of
      | increasing entropy. I've found myself cycling down the
      | street wondering if my actions were all just an elaborate
      | way of increasing entropy more quickly.
 
      | jvanderbot wrote:
      | Nobody in this thread has read Selfish Gene, apparently.
      | That's the whole point of the book: That genes may as well
      | have invented all of life to propagate themselves.
      | 
      | In this context, species conflict is like fleets of world-
      | ships fighting total war.
 
        | theGnuMe wrote:
        | Genes are effectively biological computer programs.
 
        | ok_dad wrote:
        | That's an interesting SciFi idea: the real world is
        | digital, and digital beings have created a physical world
        | to fight battle via genetic biological machines, which
        | are effectively concrete data structures.
 
        | redanddead wrote:
        | like the scene in Jurassic park
 
    | 11235813213455 wrote:
    | my machine just worries about food, and work to get food
 
| mensetmanusman wrote:
| This reminds me of the brain maggot patient that walked in the
| ER. After being cleaned up, they died the next morning.
| Apparently the symbiosis was healthy albeit disgusting.
| 
| Will be interesting if fungi end up slowing cancers and are
| actually fighting for the mycobiome.
| 
| https://en.m.wikipedia.org/wiki/Mycobiome
 
| Supermancho wrote:
| My introductory biology classes informed me well enough to
| understand that fungal infections can weaken the body's immune
| systems, weaken the tissue, or spread themselves over an inflamed
| area, with unfortunate side-effects of generating pro-growth
| local environments. Any of these may lead to an incidental
| increase in cancer growth. What's more, cancer was such a rare
| occurrence prior to WWI, you wouldn't expect that cancer rates
| would be directly related to pre-existing fungal flora.
| 
| I'm pretty sure dissected tumors have eliminated fungal
| infections as integral parts of many (if not most) cancers. If
| it's not integral, fungal is opportunistic and likely unavoidable
| for most cases. I expect that these conceptual models are what
| makes these kinds of studies difficult to prove.
 
  | jjtheblunt wrote:
  | > cancer was such a rare occurrence prior to WWI
  | 
  | why do you say that?
 
  | frereubu wrote:
  | Not quibbling with your general point, but was cancer a rare
  | occurrence before WWI on a like-for-like basis? Life expectancy
  | was a great deal lower then - it's gone up by around 30 years
  | (from just over 50 to just over 80) since then.
 
    | chiefalchemist wrote:
    | I would theorize that it was less detected prior to WW1, for
    | obvious reasons.
    | 
    | That aside, life expectancy, afaik, includes new born
    | illnesses, childhood illness and so on, and then as adults
    | there were occupational related deaths. Those brought down
    | the average then.
    | 
    | Did those who survived all those risks live as long as we do
    | today? IDK. But there has to be data to figure that out, as
    | the raw life expectancy then v now is likely misleading.
 
| agumonkey wrote:
| AFAIK fungi are extremely hard to get rid of. This is not a great
| news.
 
  | BirAdam wrote:
  | That depends upon just how much you're willing to put yourself
  | through. Compared to cancer, fungus is easy to be rid of.
 
    | hnbad wrote:
    | Yeah but that's because cancer is basically your own cells
    | with faulty programming.
 
  | etiam wrote:
  | Very diverse organism group, and often very tough, _but_ at
  | least it 's distinct organisms with distinct characteristics
  | rather than literally the same organism with some of the
  | regulation broken. We have a few chemicals that hurt them while
  | mostly sparing us, and more chemicals which hurt both but them
  | more badly.
  | 
  | Many species of fungus are quite sensitive to high
  | temperatures, which may have been one selection pressure
  | favoring warm-blooded animals. Maybe an artificial fever or
  | even local tissue heating could be enough to tip the balance in
  | favor of the host in some cases.
  | 
  | At the very least it's a fascinating piece of information which
  | is better to be in possession of than not.
 
  | 11235813213455 wrote:
  | they don't like dryness, but unfortunately our body is wet
 
| zackees wrote:
 
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