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|u/fchung - 20 hours
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|« The findings also suggest a possible explanation for why combining
|5-FU with a DNA-damaging drug often makes both drugs less effective.
|Some DNA damaging drugs send a signal to the cell to stop making new
|ribosomes, which would negate 5-FU’s effect on RNA. A better approach
|may be to give each drug a few days apart, which would give patients the
|potential benefits of each drug, without having them cancel each other
|out. »
|u/fchung - 20 hours
|
|Reference: Chen, Jung-Kuei et al., An RNA damage response network
|mediates the lethality of 5-FU in colorectal cancer, Cell Reports
|Medicine, Volume 5, Issue 10, 101778.
|https://doi.org/10.1016/j.xcrm.2024.101778
|u/Potatonet - 17 hours
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|Possibly one of the older medicines used in cancer treatment
|Considering the state of viral and immunology based therapies targeting
|the root of the gene defects in cancer these surface style chemo
|treatments are already outdated and the double triple stacking style
|that doctors used to choose is visibly not working as detailed in this
|article. It’s interesting that the doctor chose to evaluate such an old
|treatment, nice to see them show that the treatments were not
|synergistic in nature, interesting they found a new mode of action.
|Synergistic agents for this compound are generally NSAIDs and relevant
|studies can be found relatively easily that show positive synergist
|results, strange they chose to look so deep into the past to enliven
|studies on this compound Generally first line is ibuprofen and aspirin
|to be used as predominant synergists in exploratory studies, and
|generally they are effective
|https://pmc.ncbi.nlm.nih.gov/articles/PMC10377900/ I would have been
|more keen on changing the delivery mechanism, driving home the sub 20nm
|liposomal route of exposure via low pressure microfluidic synthesis
|https://pmc.ncbi.nlm.nih.gov/articles/PMC6245407/ That being said I’m
|thankful for their research!
|