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|u/towngrizzlytown - 21 hours
|
|>During ageing, bone marrow in the skull becomes an increasingly
|important site of blood-cell production. This is in stark contrast to
|most bones where the ability of marrow to make blood and immune cells
|declines. Studies in mice and humans showed that ageing results in skull
|bone-marrow expanding, and in mice this marrow was more resistant to
|inflammation and other hallmarks of ageing. The team behind the work
|hope by understanding this process better it may be possible to help
|organs become more resistant to ageing.
|u/72Pantagruel - 19 hours
|
|Awesome read. We did transplant experiments in sub-lethal irradiated
|mice some 10 years ago (CML 'stem cells') but never checked the skull
|marrow for homing of/repopulation with the human stem cells. We did find
|them in the BM and spleen. A small captain hindsight moment.
|u/Joshthe1ripper - 13 hours
|
|Can you explain to me the significance of this I have no idea
|u/72Pantagruel - 12 hours
|
|For CML we have successfully shown that the disease is already
|present in a subpopulation of the stem cells. Data was based on
|semi-solid cell culture and FISH (fluorescent in-situ
|hybridisation). Reviewer at the time was pushing for in-vivo data to
|show the cells would really be stem cell. After a lot of hardship,
|we were able to sort enough cells for an engraftment experiment
|(femural injection into sub-lethal irradiated NOD/SCID gamma mice).
|At the time the assumption was engraftment and subsequent
|repopulation of the heamatopoetic system would mainly stem from the
|BM (we did known that the flat bones also played a role, but you can
|isolate only so many targets/get enough cells to run through a FACS
|(fluorescent staining and imaging of cells based on surface
|markers). We checked lung (difficult, non significant amounts of
|human cells), spleen and BM (non-injected femur and tibia). We
|disregarded other 'flat' bones as cell yield was deemed low/not
|worth the hassle. Based on the article mentioned, we should have
|pulled cells from the skull as part of our human stem cells would
|very likely have homed and expanded there. But hindsight is always
|20/20.
|u/EarnestAsshole - 19 hours
|
|Seeing the bone marrow thickening in aging skulls kind of reminds me of
|the "chipmunk facies" we sometimes see in individuals affected by Beta
|Thalassemia, where ineffective erythropoiesis causes bone marrow
|expansion in areas like the skull.
|u/marenyOG - 19 hours
|
|This was awesome to read, thank you for posting
|