|
########################################################################
|u/AutoModerator - 1 day
|
|Welcome to r/science! This is a heavily moderated subreddit in order to
|keep the discussion on science. However, we recognize that many people
|want to discuss how they feel the research relates to their own personal
|lives, so to give people a space to do that, **personal anecdotes are
|allowed as responses to this comment**. Any anecdotal comments elsewhere
|in the discussion will be removed and our [normal comment rules](
|https://www.reddit.com/r/science/wiki/rules#wiki_comment_rules) apply to
|all other comments. --- **Do you have an academic degree?** We can
|verify your credentials in order to assign user flair indicating your
|area of expertise. [Click here to
|apply](https://www.reddit.com/r/science/wiki/flair/). --- User: u/mvea
|Permalink: https://www.nature.com/articles/d41586-024-03724-4 --- *I
|am a bot, and this action was performed automatically. Please [contact
|the moderators of this subreddit](/message/compose/?to=/r/science) if
|you have any questions or concerns.*
|u/DiscordantMuse - 1 day
|
|I feel like a lot of folks with PTSD and BPD can affirm this
|anecdotally. Emotional black-outs are what I refer to them as. When I
|feel acute stress, my ability to think or cognitively function seems to
|halt. Over time I've noticed that I struggle to recall the experience
|during that acute stress episode. It's vulnerable-making and I hate it.
|u/obrazovanshchina - 1 day
|
|Most of my childhood is gone. Lived with near constant anxiety and
|fear
|u/TheCosmophile - 1 day
|
|Hello fellow memory-orphan. Time and events do not exist for me from
|8-14, and much of high school is gone, too. You’re not alone.
|u/obrazovanshchina - 1 day
|
|It’s so strange how I normalized this for years. It was only when
|childhood friends began recalling events in adulthood I had no
|memory of or only a shadow of a memory that I realized so much of
|my childhood memories were ash. I see you. Big big hug. Lots of
|love.
|u/Ball-of-Yarn - 1 day
|
|Same to yall. I dont think a lot of us grew up.
|u/illusionsdelusions - 1 day
|
|This makes me feel so seen. I had a high school friend
|chastise me the other day because I didn’t remember something
|he did for me in high school… I don’t know how many times I’ve
|told him I don’t remember much of anything from those years…
|u/GonzoBurger - 1 day
|
|I'm adding to this thread because it's nice to find others
|like me. My girlfriend has the opposite and remembers
|absolutely everything about so everyone has a laugh when I
|can barely remember anything. It is strange though, I
|thought this would be just for my childhood but as I'm
|approaching 40 it's affected other periods too. I find I
|remember things that had a large emotional impact on me and
|everything else kind of blurs. There are some things I can
|remember if I have a cue, but otherwise, it's gone. I feel
|like I only have a handful of memories from childhood and
|losing other time periods, too.
|u/sharksarentsobad - 22 hours
|
|Fore, it's my teenage years. All I can remember is the trauma I
|experienced then and nothing happy and memorable involving friends
|or school. In contrast to my ability to remember events from as far
|back as four years old. It becomes a blank space at 13 when my Mom
|met my stepdad.
|u/obrazovanshchina - 19 hours
|
|I see you sharksarentsobad. I can relate. I don't know about you
|but it helps me to speak and write the words: I lost memory of my
|childhood and adolescence because of choices my caretaker made,
|again and again, never feeling safe. I hope there's something in
|that for you as well. I'm proud of you, of everything you are and
|are becoming. I see you.
|u/sharksarentsobad - 7 hours
|
|Thank you, I've been in therapy for years and they said I'm no
|longer exhibiting signs of PTSD. Still trying to get my GAD and
|MDD under control, but a lot of the fear and sense of feeling
|unsafe disappeared when my stepdad died. It was such a relief. I
|still feel like I'm in survival mode. I hope you're healing
|more and more every day. It's a really difficult uphill battle.
|Any progress we've made is worth celebrating.
|u/Razur - 1 day
|
|I have a distinct memory from grade school. I stuck my tongue out at
|a classmate while the teach was give a math lecture and the
|classmate did it back. The teacher pulled me aside after class and
|asked if I had started it. In the moment my brain completely went
|blank and I had no recall of what had happened. Teacher then asked
|if the other student started it, and I just went with it because it
|made the most sense since I couldn't remember. Later that day I went
|straight from a "green light" to a "red light" for lying to the
|teacher, but I had no memory of sticking my tongue out at the other
|kid first. In hindsight as an adult, I wonder if my forgetfulness
|was a stress response to being singled out and accused/scolded of a
|certain behavior. I know that I have cPTSD symptoms from when I was
|a teenager due to living in a toxic household & being constantly
|bullied, but this one specific incident makes me wonder if my trauma
|had started much earlier than I my teenage years.
|u/obrazovanshchina - 19 hours
|
|Keep asking those questions with curiosity. When I approach my
|memories as a child, those I do remember, the painful ones, with
|curiosity and not judgment. With love. With the kind of kindness I
|craved as a child but never received, I find I can hear those
|feelings speaking to me. They want to be heard. For me, I
|approach these parts of me through the Internal Family System
|framework. Works for some. Not for others. If you're interested,
|there's a book by Richard Schwartz titled No Bad Parts. I like to
|recommend it as its helped me a lot.
|u/ElderberryHoliday814 - 1 day
|
|I really think people with schizophrenia lose years because of this
|u/UkuleleZenBen - 1 day
|
|They showed on MRIs that blood flow to the prefrontal cortex (logical
|thinking, executive functioning) turns off in times of emotional
|overwhelm! That really helped me understand my ADHD/cptsd. Explains
|"brain fog" perfectly. Or why I need externally written routines to
|follow in those times
|u/MookieMoonn - 1 day
|
|I learned about this the hard way. So burnt out and un controlled BPD,
|I don't remember 2023
|u/mvea - 1 day
|
|I’ve linked to the news release in the post above. In this comment, for
|those interested, here’s the link to the peer reviewed journal article:
|https://www.cell.com/cell/abstract/S0092-8674(24)01216-9 From the
|linked article: Stress makes mice form big bundles of neurons in the
|brain that disrupt memory formation, making them fearful of harmless
|situations1 — which might help to explain why stressed people often feel
|threatened in safe environments. Researchers have long known that
|stress or trauma can lead people to fear harmless situations. For
|instance, after burning a finger on a hot pan, a stressed individual
|might subsequently avoid not only hot pans but the kitchen or cooking
|entirely. This kind of generalized fear is common in people with post-
|traumatic stress disorder (PTSD) and generalized anxiety disorder. A
|study, published in Cell, describes how stress disrupts memory formation
|and, in particular, recollections of fearful events. The results could
|inform the development of therapies for people with PTSD and anxiety.
|“This paper is really a tour-de-force,” says Ryuichi Shigemoto, a
|neuroscientist at the Institute of Science and Technology Austria, in
|Klosterneuburg. “They used so many different methods and techniques to
|prove this long pathway.” The team were able to reverse the effects of
|stress on memory formation with two drugs, one of which is approved for
|terminating early pregnancy, mifepristone. The drugs either block the
|glucocorticoid receptors or the production of endocannabinoids, and the
|stressed mice recalled memories in the way that unstressed mice did.
|u/Sara_Sin304 - 1 day
|
|Fascinating thank you!
|u/CMC04 - 1 day
|
|So would it be possible that you don’t remember as much of your
|childhood as a lot of people seem to because it may have been more
|stressful?
|u/Brrdock - 1 day
|
|I think most people would attest to that, at least. But once I really
|got to processing and working on my problems as an adult, I also
|started remembering more about it, good things, too. Could be that
|fight-or-flight makes memory more selective, too. At least it does
|direct attention, and those are very connected, at the moment and
|retrospectively. This sounds amazing, though I wonder what the side-
|effects are of blocking glucocorticoid receptors or production of
|endocannabinoids. Hopefully more tolerable than those of current drugs
|u/Skittlepyscho - 1 day
|
|I have been diagnosed with GAD and PTSD. I started a new job last year
|that I've been working towards since I graduated with my masters degree
|in 2017. I worked really hard to get this job that I'm qualified for,
|and I was so excited to finally reach my goal! However, I got there and
|was very stressed out, which is totally normal in a new environment and
|a high paced job. My brain would shut down, and I couldn't even do basic
|tasks because my brain wouldn't be able to perform. Doing simple tasks
|like scheduling a Teams call became incredibly difficult for me to do.
|I ended up getting let go because I wasn't able to perform- even though
|I studied the topic for 6 years and have a bachelors and masters degree
|in the area.
|u/I-hope-I-helped-you - 1 day
|
|Same. I am heavily medicated to perform my job. SSRI and 25mg
|quetiapin for sleeping.
|u/apoletta - 1 day
|
|Sounds a lot like me. To the point of self sabotage.
|u/LeeGhettos - 18 hours
|
|You are literally in a science sub, in a conversation about the
|pathway that makes these reactions exist. Accusing a stranger of
|self sabotage because of extremely typical symptoms of a disorder is
|extremely fucked.
|u/apoletta - 15 hours
|
|I have done this to myself. Therapy has been good for me. Perhaps
|it could help op.
|u/justwalkingalonghere - 20 hours
|
|That's just rude. It sounds more like they need to seek counseling
|and psychiatry than it being self-sabotage
|u/ShelIsOverTheMoon - 1 day
|
|Have you tried medication?
|u/Skittlepyscho - 20 hours
|
|Yes! I'm on an SSRI
|u/ShelIsOverTheMoon - 8 hours
|
|I'm glad you're taking care of yourself in that respect. And I'm
|sorry for your troubles. Hang in there, friend.
|u/old_and_boring_guy - 1 day
|
|I think of it more as understanding that even seemingly harmless
|situations can go awry. Lot of PTSD arises from situations that go from
|peaceful to deadly in an instant with no warning.
|u/Less_Wealth5525 - 1 day
|
|Well mifepristone won’t be around for long.
|u/amy-schumer-tampon - 1 day
|
|where do i get these drugs
|u/Halsfield - 1 day
|
|why does blocking endocannabinoids help with ptsd/anxiety? i wouldve
|thought it would help but im also one of those people that gets horrible
|anxiety attacks from cannabis.
|u/untss - 1 day
|
|> why would endocannabinoid inhibition improve anxiety symptoms >
|cannabis causes anxiety in me maybe your experience is more the rule
|than the exception
|u/JoanOfSarcasm - 1 day
|
|Ii have GAD, PTSD, and panic disorder. Cannabis gives me horrible
|anxiety. Anecdotal but I don’t know anyone with severe anxiety who can
|smoke large amounts ofcannabis without increased anxiety, panic, and
|paranoia. I smoked on/off for years until cannabis started being
|grown so strong that it was easy to overshoot my sweet spot. Last time
|I tried a 5mg edible, it had a bunch of additives for absorption I
|didn’t see and I ended up vomiting all night. That was the end for me.
|E: I mean large amounts of cannabjs. I should’ve clarified that. I had
|an amount I could smoke that often would relax me, but I needed a
|specific strain that was VERY rare and a low THC %. Most dispensaries
|are growing cannabis stronger and stronger these days, which makes it
|tough to find a therapeutic dose.
|u/_Fl0r4l_4nd_f4ding_ - 1 day
|
|I have GAD and panic attacks and weed is my saviour in those
|situations where i cant calm down.
|u/FrillyLilly - 1 day
|
|I have GAD, PTSD, OCD, and agoraphobia. I smoke/vape weed nearly
|constantly in order to remain more “chill” however if I do too much
|too fast, especially with edibles, I can trigger a panic attack,
|paranoia, vomiting, etc. I learned my limits over time and I try to
|stay within them so that cannabis remains therapeutic for me.
|u/IamGoldenGod - 22 hours
|
|I have anxiety issues and weed definitely makes it worse, however
|weed acts like an antidepressant for me quite well if I don't overdo
|it. So there is a sweet spot I'm always trying to get to but I often
|over/undershoot it.
|u/JoanOfSarcasm - 18 hours
|
|Yeah this was my issue. My sweet spot is very low (and edibles
|didn’t have the same feeling for me) and most cannabis now is
|grown so strong that it was easy to overshoot it. It wasn’t worth
|the bad side effects for me.
|u/Halsfield - 1 day
|
|my brother has PTSD and smokes constantly w/o panic attacks so i
|dont know whats going on here.
|u/kimchidijon - 1 day
|
|I’ve been dealing with GAD my whole life and PTSD from multiple
|traumatic events that happened starting 2019. I don’t remember my
|childhood at all, it’s completely blank.
|u/archival-banana - 1 day
|
|Same here, turbulent childhood. Was the adult in the adult-child
|relationship with my mom. All of my childhood from when I was 5-17 is
|extremely fuzzy, impossible for me to form a timeline of events. But
|whenever someone mentions an event that happened during that time
|frame, my brain remembers it clear as day. Especially traumatic
|events. It’s fascinating how our brain reacts to and helps us cope
|with trauma.
|u/LongSchlongdonf - 1 day
|
|Block production of cannabinoids. Funny I have IBS and it’s really
|helped by weed and all and it’s funny one of the theories for why is
|that IBS could actually be caused by an endocannabinoid deficiency
|u/infrareddit-1 - 1 day
|
|Thanks for posting about this important work. Anybody have access to the
|full paper?
|u/Alternative_Belt_389 - 1 day
|
|I worked in one of the author's labs...horrible human
|u/JEMinnow - 19 hours
|
|It’s terrible what PI’s can get away with in academia
|u/Alternative_Belt_389 - 17 hours
|
|I landed in the ER because of the stress, micro management, and
|toxicity. I'm out of research now and much happier. These PIs need
|to be held accountable. Plus this group practices shady science...
|u/JEMinnow - 17 hours
|
|Wow, I'm glad you got out. How long did it take to recover? I'm
|in a masters program and my PI seemed really nice at first, but I
|can see now that she's straight up mean and insecure, despite
|being an established medical doctor. I needed training in the
|beginning and she paired me up with a woman who had a history of
|abusive behaviour. Over the course of 6 months, the woman
|training me got more demanding and controlling. When I finally had
|enough and called her out, I was made to feel like a bad person,
|by her and my PI. They basically gaslit me and my PI reminded me
|that the woman who trained me had 2 masters degrees, as if it
|justified her behaviour. Well, it escalated, and eventually the
|woman who trained me got fired because our project manager got
|wind of how I was being treated. Later, I found out that the
|woman who trained me had been horrible to other employees, so I'm
|pretty pissed that I was stuck with her for months. When I brought
|it up, my PI told me that I was never obligated to meet with that
|woman regularly. That's how poor the communication is on our
|'team'. Well, now my PI hates me and I think it's because she
|sees me as the reason why one of her best employees isn't there
|anymore, rather than the toxic environment (I say best because the
|one who trained me was a brilliant programmer but a terrible
|person). Now, my PI acts like a bully, but it's so covert I
|wouldn't be able to to call her out. For example, making me look
|stupid in meetings, not giving me all the information I need to
|improve presentations, giving me nasty looks, acting annoyed
|whenever I speak. Just all round awful and unfortunately she's my
|primary supervisor. I have 5.5 months to go (hell yes I'm
|counting) and I can't wait to be done, omg. I'll be crawling
|across that finish line and I honestly don't hate a lot of people
|but I'm starting to hate my supervisor. Will she ever be held
|accountable for not protecting a vulnerable student and then
|basically gaslighting and being a bully? Nope.
|u/Less_Wealth5525 - 1 day
|
|My sister doesn’t remember the first seven years of her life.
|u/tollbearer - 1 day
|
|Are you supposed to remember anything from childhood? I have like 5
|memories from before 12.
|u/Saggy_G - 20 hours
|
|Hello fellow trauma survivor.
|u/LeeGhettos - 18 hours
|
|Unfortunately, yes you are. You are solidly atypical in that regard,
|and it’s often a sign of trauma.
|u/tollbearer - 8 hours
|
|I don't think I have any major traumas. To be honest, I think a
|lot of it is just that I didn't do anything. Never went on
|holidays, didn't have any hobbies, no extended family, had like 1
|friend, 1 grandparent... Life was just school, tv, sleep. I do
|remember the few times my grandfather took me on holiday. So I
|think it's more a lack of anything to remember, than blocking out
|anything
|u/goldenbugreaction - 8 hours
|
|Were any other adult caretakers part of your early life, or just
|your grandfather?
|u/tollbearer - 5 hours
|
|Both my parents were present. My grandfather died when I was
|10.
|u/archival-banana - 1 day
|
|Yes, you are.
|u/ArcticCircleSystem - 1 day
|
|So they gave mice PTSD to see how stress affects memory?
|u/OG-TRAG1K_D - 1 day
|
|Punch mouse, mouse squeak, punch mouse, mouse squeak! Mouse scared of
|light and punches!!!
|