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Genetic analysis reveals role of melatonin in ADHD symptom severity |
Study found that genetic variations affecting melatonin production could
contribute to ADHD symptoms, particularly through disrupted sleep
patterns.
https://www.psypost.org/genetic-analysis-reveals-role-of-melatonin-in...
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|u/chrisdh79 - 2 days
|
|From the article: New research [published](https://www.sciencedirect.com
|/science/article/pii/S2772598724000345) in Psychiatry Research
|Communications suggests that the hormone melatonin may be closely linked
|to the severity of attention deficit hyperactivity disorder (ADHD)
|symptoms in children. A study led by Hamamatsu University School of
|Medicine found that genetic variations affecting melatonin production
|could contribute to ADHD symptoms, particularly through disrupted sleep
|patterns. These findings highlight the potential benefits of healthy
|sleep routines in managing ADHD symptoms.  Melatonin is a hormone
|naturally produced by the pineal gland in response to darkness, helping
|regulate sleep-wake cycles. It signals the body when it’s time to sleep,
|supporting our internal “biological clock,” or circadian rhythm.
|Disruptions in melatonin production can make it harder to fall asleep,
|affecting sleep quality and overall well-being. Melatonin has other
|roles as well, including supporting immune function and reducing
|inflammation.  For many individuals, melatonin secretion follows a
|predictable pattern, rising in the evening and lowering in the morning.
|However, this pattern can vary, and certain conditions may interfere
|with typical melatonin levels, disrupting the sleep cycle.  ADHD, a
|neurodevelopmental disorder, is characterized by symptoms of
|inattention, hyperactivity, and impulsivity. For children with ADHD, one
|common challenge is establishing a stable sleep routine. Many struggle
|to fall asleep on time, which worsens their daytime symptoms and leads
|to a cycle of sleep deprivation and increased hyperactivity or
|inattention.  While ADHD’s exact causes are complex, involving genetic,
|neurological, and environmental factors, recent research suggests that
|sleep disruptions could be a contributing factor. Specifically, children
|with ADHD often exhibit delayed melatonin secretion, which might be
|linked to difficulties in winding down and falling asleep at night.
|“Sleep disturbances are common in children with ADHD, yet the mechanisms
|are not fully understood. Our interest stemmed from the hypothesis that
|disrupted melatonin secretion, a key regulator of circadian rhythms, may
|play a role in ADHD, potentially linking sleep patterns with genetic
|risk factors,” said study author Nagahide Takahashi, who is now a
|director in the Department of Neurodevelopmental Disorders at the
|National Center of Neurology and Psychiatry in Tokyo.


  |u/spiritussima - 2 days
  |
  |Melatonin is as crucial to treating my kid's ADHD as stimulants.


    |u/whyshouldiknowwhy - 1 day
    |
    |I’m glad I’m not the only one! I take LixDex 40mg (vyvanse) every
    |day and 4mg melatonin on a night. I would struggle without both


      |u/askingforafakefriend - 1 day
      |
      |Vyvanse is a godsend... I don't think any dosage of melatonin is
      |psychoactive noticably for me. Trazodone every night helps
      |immensely and seems to improve sleep architecture anyway though.


        |u/dastree - 1 day
        |
        |I love trazodone to help me sleep, I hate the restless leg that
        |comes with it if I take it too early though


      |u/concreteghost - 1 day
      |
      |How long you been on that regimen?


        |u/whyshouldiknowwhy - 1 day
        |
        |About a year and a half. I take my meds on and off. I’ve been
        |diagnosed since 2017


          |u/concreteghost - 20 hours
          |
          |You’ve never had to up the melatonin?


            |u/whyshouldiknowwhy - 16 hours
            |
            |Nah, mind, I probably take it 1/2 of the time


  |u/NorysStorys - 2 days
  |
  |I mean if you asked anyone with ADHD this, they could have told you
  |all of this. I’ve not had a good night sleep for over 20 years at this
  |point.


    |u/GamerLinnie - 2 days
    |
    |That is true for some but not all.  I for example sleep amazing. I
    |fall asleep easily and stay asleep.  It is also an interesting
    |chicken and egg situation. It would be great if we can treat some
    |kids with melatonin instead of other meds.


      |u/polypolip - 2 days
      |
      |I sleep without issues, once I'm in bed I fall asleep almost
      |immediately. I have problem getting to bed. And then I have
      |problem waking up. If I sleep in total darkness, with blinds down,
      |I won't properly wake up for like 12h.


        |u/Supergaz - 1 day
        |
        |I do a trick, set two alarms, one 20 minutes before the "real"
        |alarm. Take medication on the first alarm, by the second alarm
        |the medication is in my bloodstream and I wake up like a normal
        |person. Ofc always have water and medication by your bed etc.
        |As far as I know, the waking up process is pretty messed up in
        |Adhd people, so it all makes sense.  Also the medication being a
        |stimulant obviously makes it much easier to wake up.  My sleep
        |quality is very ass, but I think that comes down to being really
        |slim and not having a soft enough bed and being really bad at
        |keeping a normal sleep schedule.  I don't have issues falling
        |asleep or getting up, but going to bed, regardless of being
        |tired or not, I am super bad at getting up and going to bed. It
        |is way way too easy to procrastinate going to bed and suddenly
        |everything is fucked as hell


          |u/patchgrabber - 1 day
          |
          |Couldn't you just do the same by hitting snooze?


            |u/Supergaz - 1 day
            |
            |I could, but snooze is 5 minutes per default and I have to
            |be sure the second one works for sure


              |u/patchgrabber - 1 day
              |
              |5 minutes? Mine defaults to 10, I've never heard of
              |defaulting to 5, that's more like a snoo not a snooze. But
              |either way you do you boo.


                |u/Supergaz - 1 day
                |
                |Ye it works


          |u/polypolip - 1 day
          |
          |I used to drink a cup of coffee before going to bed whenever I
          |wanted to wake up on time. I started meds not long time ago
          |and I prefer to take it after food, so your trick might not
          |work for me.


            |u/Supergaz - 1 day
            |
            |Coffee before sleep is not good, it kills sleep quality.
            |Also yeah, it is hard to eat breakfast after taking meds on
            |an empty stomach. If appetite becomes an issue with meds
            |drinking less coffee helps. If I drink coffee and take meds
            |at the same time, my stomach gets sad


              |u/polypolip - 1 day
              |
              |Sleep quality is not the best for me but strangely I feel
              |more rested in the morning. I pretty much quit coffee for
              |the meds, now I drink it only when I forget to take meds.


        |u/XForce070 - 2 days
        |
        |Yes same for me. Which is due to what this study says i guess.
        |You don't have the urge to go to bed due to the lack of
        |'tiredness'. I think this is generally already very accepted
        |since this sleep schedule is a very big part of my current
        |treatment, event going as far that they offer sleep studies for
        |those with ADHD. If I understand correct this article is mostly
        |about the reason why melatonin production is different in people
        |with ADHD


        |u/frankyseven - 1 day
        |
        |Yep. Sleeping isn't the issue, going to bed is. I'm told I have
        |a gift for sleeping, but going to bed sucks.


        |u/tequilavixen - 1 day
        |
        |Yup this is my ADHD sleep in a nutshell. Plus all the brain fog
        |unless my meds are in full swing. Ironically enough, I got a
        |sleep study done and turns out I have textbook perfect sleep


          |u/nomellamesprincesa - 19 hours
          |
          |I haven't been diagnosed with ADHD (yet), but I strongly
          |suspect I have it, struggling a lot with brain fog and with
          |sleeping patterns (falling and staying asleep is easy, going
          |to bed much less so, getting out of bed is near impossible),
          |am always exhausted walking up, I also had a sleep study done
          |(in the framework of a citizen science project on the effects
          |of noise pollution on health), also perfect sleep here.


      |u/The_Singularious - 2 days
      |
      |I wish melatonin worked for me. Have an ADHD Dx, and get brutal
      |nightmares when I take melatonin. Same for my daughter.


        |u/babar001 - 1 day
        |
        |Same. Worse with instant release, manageable with extended
        |release.


          |u/The_Singularious - 1 day
          |
          |I haven’t tried the latter. Ty for bringing it to my
          |attention.


            |u/sweng123 - 1 day
            |
            |They also come in patches, now. Instant release always
            |messed with me, as well, but not the patches.


              |u/The_Singularious - 1 day
              |
              |Ty. Good to know.


        |u/spiritussima - 1 day
        |
        |What about guanfacine? Used as a non-stimulant ADHD medication
        |but also makes people sleepier (and I wonder how much of it is
        |treating the sleep issues and in turn helping ADHD)


          |u/The_Singularious - 1 day
          |
          |Have not tried that. Good news is that low-dosage Adderall is
          |super effective for my ADHD. But yeah, regular sleep would be
          |helpful.   I get some relief from valerian/passionflower tea,
          |and Lemon Balm tablets.   But thank you. Gonna speak with my
          |doctor about it.


        |u/MediocrePotato44 - 1 day
        |
        |I have the same issue with it, on top of it making me skin crawl
        |and inducing restless leg syndrome.


        |u/ditchdiggergirl - 1 day
        |
        |That may be the dose - high dose melatonin reduces sleep
        |quality. You should keep your dose at 1.0 mg or less. I normally
        |take 0.3 mg as per my physician, and can handle 1 mg, but when I
        |have gone over 1 mg I get the psycho dreams.


        |u/brit_jam - 1 day
        |
        |Have you tried magnesium glycinate?


        |u/KwekkweK69 - 11 hours
        |
        |I get sleep paralysis with melatonin


          |u/The_Singularious - 11 hours
          |
          |Oh wow. That is seriously unfun.


      |u/Taway7659 - 2 days
      |
      |Oral melatonin doesn't do *anything* for me personally. I did a
      |fistful of gummies at one point in exasperation. My limited
      |experience with conventional ADHD medication on the other hand has
      |me going to sleep organically and waking up with the dawn.


        |u/zombienudist - 2 days
        |
        |Have you tried a timed released melatonin? I have tried regular
        |and found it gave me strange dreams and then I would be up at
        |3am.  So I tried timed released version and it is much better
        |and keeps me asleep for most of the night.


          |u/Fragsteel - 2 days
          |
          |Oh man, I'm gonna look up the time release version, I've had
          |the 3am thing consistently lately.


            |u/zombienudist - 2 days
            |
            |Don't overdo the dosage as I found that can lead to
            |headaches and fogginess the next day.   I typically take 5mg
            |of timed released right before bed along with magnesium and
            |while my sleep is not perfect it is much better than it has
            |been in years.


              |u/Fragsteel - 1 day
              |
              |Yeah I heard too much melatonin can also create a
              |dependence. I'm on 3mg now, also with magnesium taurate.
              |Good looking out!


              |u/ImObviouslyOblivious - 1 day
              |
              |What does taking magnesium  With it do?


                |u/zombienudist - 1 day
                |
                |I just take it along with Melatonin to help with sleep
                |also.   There is some evidence that it helps promote
                |lower anxiety and muscle relation along with a number of
                |other benefits that help with sleep.    [Magnesium for
                |Sleep: Benefits, Risks,
                |Tips](https://www.health.com/condition/sleep/magnesium-
                |for-sleep)


                |u/Fragsteel - 1 day
                |
                |I take it because it supposedly has a positive effect on
                |amphetamine tolerance, and I take Adderall. But you
                |can't just get the store bought kind for that, that's
                |always a cheaper version that apparently doesn't work as
                |well for that purpose.


          |u/Taway7659 - 1 day
          |
          |I have not: I'll give it a shot.


        |u/GamerLinnie - 2 days
        |
        |It does wonders for my son. His entire life bed time was a
        |struggle. There were days when he would cry because he was so
        |tired but he couldn't sleep.  Other days he would stay in bed
        |but would fall asleep super late.  I had read an article about
        |the importance of sleep in kids and bought him a super low
        |children specific dose.  It was the first time he slept at a
        |decent time without any issues. I took him to the GP the next
        |week and it was the first day in him getting his diagnosis. He
        |now also takes ritalin but the biggest change has been the
        |melatonin.  He himself says that now he feels the sleepy switch
        |and he starts to get sleepy instead of just tired.


        |u/ditchdiggergirl - 1 day
        |
        |Fistful??? No wonder you couldn’t sleep. It’s a hormone, it’s
        |not dose dependent and high doses can interfere with sleep
        |quality. The recommended range is 0.3-1.0 mg.


          |u/Taway7659 - 1 day
          |
          |That was an expression of the ends I'd gone to. Lowest OTC
          |dose didn't work, next dose didn't work, some steps later the
          |family who insisted it works fine for them added some weight
          |and I did what I said.


        |u/Moldy_slug - 1 day
        |
        |Same here. When I’m taking adderall during the day I have a much
        |easier time going to sleep at an appropriate time and waking up
        |in the morning.


      |u/Nobanob - 1 day
      |
      |Same however my biological clock wakes me up between 6-7 everyday
      |and has for decades. I don't need to, I don't want to, and it
      |prohibits me from staying out very late. As I still wake the same
      |time every day regardless


      |u/TripleSecretSquirrel - 2 days
      |
      |Ya, I have ADHD hardcore but I’ve never had trouble falling or
      |staying asleep.


      |u/Momoselfie - 1 day
      |
      |Yeah my daughter is a deep sleeper too and usually can fall asleep
      |pretty fast. Sometimes her ADHD makes it hard for her to sit still
      |and go to sleep, but it's not usually an issue.  I think part of
      |her ADHD stems from just being too excited about too many things
      |at once, not from lack of sleep.  I do struggle with sleep but I
      |get that from my mom. My dad sleeps fine and he's the one my ADHD
      |comes from.


    |u/Gastronomicus - 1 day
    |
    |> they could have told you all of this.  They could have told you
    |they express delayed melatonin secretion? They all have access to
    |biomedical facilities that allowed them to measure this across a
    |wide array of other subjects with ADHD?  Responses like yours are
    |incredibly unhelpful in r/science.


      |u/NonConRon - 1 day
      |
      |What is this delay called? I can't sleep right now.  It fucks up
      |my whole damn life.


    |u/zombienudist - 2 days
    |
    |Have you tried taking melatonin?  As an adult with ADHD who has
    |struggled with sleep for the past 20 years what finally worked for
    |me was timed released melatonin.   Regular gave me vivid dreams and
    |had me awake at 3am.   But timed released has helped me stay asleep.
    |I generally take that along with magnesium at night right before I
    |go to bed.   While my sleep is not perfect it is far better than it
    |has been in years trying this.


      |u/NorysStorys - 1 day
      |
      |Not available in the UK without a prescription and that
      |prescription can only be given on a formal diagnosis of a relevant
      |condition, of which I’m currently on a 5-10 year waiting list to
      |be assessed.   No option to go private to speed it up because the
      |inability to sleep keeps me out of work and on disability welfare.
      |It’s all incredibly dumb because many therapists have concluded
      |that it’s ADHD causing my issues but unless a specifically
      |qualified Psychologist assesses me, I’m just stuck.


        |u/zombienudist - 1 day
        |
        |And I thought Canada was strict on some of this stuff.  Here it
        |is just available to anyone without a prescription like most
        |other vitamin supplements.   The bottles do say to consult with
        |your physician before long term use.  I actually was at my
        |doctors two weeks ago and discussed it and he said there was
        |zero problem taking it long term.


          |u/NorysStorys - 1 day
          |
          |It was set up that way in the 90s because Melatonin was being
          |overused by people who then faced issues later. They
          |overreacted though as it’s more common for zopiclone is more
          |easily prescribed than Melatonin


    |u/i-Ake - 1 day
    |
    |I used to cry until I fell asleep most nights as a kid. My brain
    |would not turn off. I would just stare at the ceiling for hours and
    |cry. I forgot about it til now... the nights felt so long and
    |lonely.  My mom hated when I got into their bed at night, too. They
    |had a waterbed, and I used to try to balance myself on the wooden
    |edge of my dad's side so I wouldn't make waves, but my Mom would
    |always feel me movi g and kick me out. Ow, childhood. I forgot about
    |all that. I sleep *better* now, compared to that, but not great.


    |u/AftyOfTheUK - 1 day
    |
    |Lived my whole life with ADHD. I used to sleep like the dead until
    |30. It wasn't uncommon in my teens/twenties to sleep until midday.
    |Now I'm in my fourties I need chemical help to sleep a few hours at
    |a time.  Everyone is different, and age changes us.


    |u/Bamith - 1 day
    |
    |Weed gummies sometimes helps, or in the very least I don’t mind it
    |as much when tossing and turning.


    |u/dendudes123 - 1 day
    |
    |facts man at this point i sometimes take melatonin to fall asleep
    |earlier or smoke a joint. just anything so i can fall asleep at a
    |normal time.  waking up tired is such a drag on life


    |u/JesseBrown447 - 1 day
    |
    |I may have had a few good night's sleep my entire life. Most days,
    |it's tossing and turning and waiting for sleep that never comes.


    |u/Knerd5 - 1 day
    |
    |Have you tried ear plugs? I started using them and it makes a big
    |difference. That plus a blackout curtain making the room pitch
    |black.


      |u/TurbinesGoWoosh - 1 day
      |
      |Black out curtains are amazing! But if I use earplugs, I'm left
      |with only the deafening "sound" of my tinnitus.  Tinnitus is
      |particularly noticable at night when there isn't any other noises.
      |So using something to produce a consistent background or white
      |noise (ie: air purifier or fan) helps "drown out" the tinnitus. I
      |also like "headband headphones" for sleeping to play some white
      |noise if I'm having a particularly bad night. They're great for
      |side sleepers and those who move around often.  But a really
      |helpful thing to do to promote melatonin production is to not stay
      |up scrolling on your phone and turn off the lights. Even a small
      |amount of light is enough to inhibit melatonin production. It's a
      |hard habit to break tho, especially with ADHD. I'm still working
      |on it myself.


  |u/it-was-justathought - 1 day
  |
  |They could probably also tell you that waking up sucks- for me worse
  |than not getting to sleep on 'time'. It's more than just not enough
  |sleep- Do they know what the rise an fall of the melatonin levels were
  |in the kids? IE were there abnormal levels in the morning?


  |u/Octopus_ofthe_Desert - 1 day
  |
  |My adoptive mother destroyed my ability to sleep easily as a child.
  |She would give me many times an adult dosage of Melatonin to me when
  |she didn't want to deal with me. I was as young as five or six. 
  |Found out a few years ago I have ADHD, CPTSD, now I find out the
  |insane creature that kept me away from the world for the first 11
  |years of my life has left yet another scar on me.    I'm going for a
  |beer


  |u/Sporkers - 1 day
  |
  |Or the increase in ADHD is from parents being too lax with
  |establishing and enforcing good sleep routines for their children from
  |a young age....?


    |u/zombienudist - 1 day
    |
    |In the book Why We Sleep by Matthew Walker he discusses this and how
    |many childhood ADHD diagnoses could actually be chronic sleep
    |deprivation.  So there has to be great care in making sure that a
    |childhood diagnosis of ADHD is actually that and not chronic lack of
    |sleep.  Here is part of what he says.  "An added reason for making
    |sleep a top priority in the education and lives of our children
    |concerns the link between sleep deficiency and the epidemic of ADHD
    |(attention deficit hyperactivity disorder). Children with this
    |diagnosis are irritable, moodier, more distractible and unfocused in
    |learning during the day, and have a significantly increased
    |prevalence of depression and suicidal ideation. If you make a
    |composite of these symptoms (unable to maintain focus and attention,
    |deficient learning, behaviorally difficult, with mental health
    |instability), and then strip away the label of ADHD, these symptoms
    |are nearly identical to those caused by a lack of sleep. Take an
    |under-slept child to a doctor and describe these symptoms without
    |mentioning the lack of sleep, which is not uncommon, and what would
    |you imagine the doctor is diagnosing the child with, and medicating
    |them for? Not deficient sleep, but ADHD."


      |u/Sporkers - 1 day
      |
      |Thank you, this is very informative.


    |u/Koreus_C - 1 day
    |
    |It's tooth paste with fluoride and caffeine in pregnancy.


|u/Accomplished_Trip_ - 2 days
|
|Is that why sitting in the dark makes it too boring to sleep?


  |u/poemmys - 2 days
  |
  |“Too boring to sleep” is a good way to put it. I need a tv or
  |something on so I can distract my mind from thinking. I basically have
  |to trick my brain into letting me sleep.


    |u/Lachshmock - 1 day
    |
    |For me it's long YouTube science videos, works a treat. I like to
    |think the information subtly seeps into my brain while I sleep.


  |u/Fragsteel - 2 days
  |
  |Audiobooks have done wonders for me in this regard. I wasn't even a
  |reader, especially not fiction. But having something to pay attention
  |to without the visual stimulation is very helpful.


    |u/robotsongs - 1 day
    |
    |How do you maintain cohesion throughout the book? If it just keeps
    |playing while I sleep, how do I find out where I last listened in a
    |36-hour recording? Even if I do a timer, I'll either fall asleep too
    |soon and have to scroll a bunch to find where I was at, or it stops,
    |I'm jolted awake, and then I have to spend the next hour or two
    |trying to fall back asleep.   What's your solution?


      |u/Fragsteel - 1 day
      |
      |I do use a timer, and that helps, but figuring out where I had
      |stopped the night before is indeed inconvenient. But, as I was on
      |my way to sleep that time, it's not so bad to err on the early
      |side and re-listen to a short bit.  Though the book turning off
      |doesn't wake me up. That's a new one to me.


    |u/Ratfit - 17 hours
    |
    |Works well for me too but I have to be careful because I’ve woken up
    |in a panic on more than one occasion because the book took a turn
    |and suddenly something awful happens to a character and the voice
    |actor starts crying/yelling/speaking in the worlds creepiest voice


  |u/Incarcer - 13 hours
  |
  |My personal solution is have something on that you're familiar with.
  |You have something to fill the silence and you know what you're
  |missing, so easier to keep your eyes closed. Sometimes you drift off
  |with it, and sometimes you sort of tune it out, but it still oddly
  |occupies the mind enough and then you hopefully drift off. Something
  |that covers my eyes helps a lot too.   Everyone has to find their own
  |little 'system'


|u/Jubjub0527 - 2 days
|
|Where can I like, sign up for this? Put me through brain scans, mris,
|he'll crack my head up and poke around to see if you unlock a hidden
|memory. Just tell me what's going on in there.


  |u/Haldoldreams - 1 day
  |
  |Unfortunately most clinical research studies share very limited
  |individualized data with participants, especially experimental
  |results. Sharing such information conflates research with medical care
  |which is an ethical no-no. Also, it is difficult for laypeople to
  |grasp the uncertainty of experimental results so by sharing this
  |information you run a big risk of giving people false impressions. 


|u/the__mom_friend - 2 days
|
|This is so interesting because when my son (now diagnosed with ADHD) was
|younger we tried giving him small doses of melatonin to help regulate
|his sleep schedule. (I promise it was under our pediatrician's guidance,
|poor little guy was getting no rest and we were desperate).  We
|immediately stopped because it gave him horrific night terrors! I wonder
|if some of this is why?


  |u/williamshakemyspeare - 1 day
  |
  |This happened to me at doses that were too high. I had great results
  |with 1mg tablets, which is smaller than most stores carry for some
  |strange reason.


    |u/321gogo - 1 day
    |
    |This. I even bite a third of 1mg at a time. Also I’ve found the
    |dreams come mostly when the melatonin gets me to sleep far off my
    |sleep schedule. Like if I am trying to sleep > 1hr earlier than the
    |night before.


  |u/zombienudist - 2 days
  |
  |The same thing happened to me when I tried normal melatonin as an
  |adult who has ADHD.   Not night terrors but very strange vivid dreams
  |that were far too intense.  Then I would be up at 3am and not be able
  |to fall back asleep.   For me I didn't really start struggling with
  |sleep until I was in my 30s after I had kids and turned to drugs and
  |alcohol to help.   After quitting drugs and alcohol I have tried just
  |about everything.   What finally worked for me was timed released
  |melatonin in the right dosage.   I find that 10mg is too much.   5mg
  |of timed released is the right amount for me but of course everyone is
  |different.  It does make some kind of sense that you are taking a dose
  |of melatonin, and a typical pill will give you that does all at one
  |time while a timed-release version will take 6 hours or so to get into
  |your system.   While not perfect my sleep is far better than it has
  |been in years doing that.   So something for them to try if sleep is
  |still difficult for them.


    |u/wollflour - 1 day
    |
    |Would you be willing to share the brand name or where you get your
    |timed-release melatonin? It looks like some brands that say they are
    |time-release aren't super legit (as they come in gummies, which
    |seems impossible to do a timed dose). I'd like to try but would
    |prefer not to waste money on a non-legit brand. Thank you!


      |u/zombienudist - 1 day
      |
      |I use the Weber Naturals Melatonin Extra Strength.   I am in
      |Canada and it is carried at a lot of places including Walmart
      |here.   Don't know if you can get that kind elsewhere though.
      |[Melatonin 5 mg Time Release Tablets | Webber
      |Naturals](https://webbernaturals.com/products/melatonin-5-mg-
      |timed-release-tablets?variant=40995009364047)  The bottle says to
      |take 1-2 tablets but I find that 2 was too much and led to me
      |having headaches and grogginess the next day.   So I stick to one
      |tab a night or a 5mg dose.


    |u/kimbabs - 1 day
    |
    |Woah, I thought I was the only person that had these strangely vivid
    |dreams on melatonin.  It became so bad I couldn’t tell my dreams
    |from real events. I had to stop.  What was most frustrating is I
    |didn’t always feel sleepy on it either, just… oddly detached from
    |reality.


      |u/ditchdiggergirl - 1 day
      |
      |No, lots of people do. It’s dose related; high dose melatonin
      |reduces sleep quality. The therapeutic range is 0.3-1.0 mg, but I
      |haven’t seen 0.3 in the stores in over a decade. I can tolerate 1
      |mg but any higher and I get the psycho dreams.


  |u/___Jet - 1 day
  |
  |Same here, helps me fall asleep fast but straight up horror dreams


  |u/amanda77kr - 19 hours
  |
  |Both me and my mom have very vivid dreams on melatonin. She hates it,
  |most of hers are bad dreams. It’s a very common side effect. Valerian
  |root and CBD are other options. Weirdly I also find exercise within a
  |couple hours of bedtime helps.


|u/maraemerald2 - 1 day
|
|I wonder if that’s part of why stimulants help ADHD symptoms so much.
|We’re just tired!  I know I for sure don’t really ever fall into a
|“sleep pattern”. Even going to bed at the same time every day and
|getting up at the same time, I still have to set a “go to bed” alarm or
|I naturally stay up hours too late. My body just doesn’t tell me to go
|to bed on time.


  |u/ditchdiggergirl - 1 day
  |
  |The causal arrow clearly points in the other direction for me. I
  |refused to take ADHD meds for most of my life, except intermittently
  |but I didn’t care for it. A few years ago my doc talking me into
  |trying another (ritalin) and my sleep greatly improved. I can miss one
  |dose without ill effects but if I miss a couple of doses (common,
  |because, you know, ADHD) I can’t sleep.


  |u/Archinatic - 1 day
  |
  |I think there is a lot of basis for ADHD primarily being a condition
  |of bad sleep. About 50% of pediatric ADHD cases suffer sleep
  |disordered breathing (such as sleep apnea). These are physical
  |conditions that impair sleep quality due to obstructed breathing. It
  |is mainly caused by environmental factors that in turn lead to
  |allergies, obesity, bad jaw development, etc. Daytime sleep apnea
  |symptoms are also helped with stimulants. They just don't treat it
  |that way because we have an actual fix which is to prevent breathing
  |disturbances from occuring. This raises serious questions about ADHD
  |being a purely genetic neurodevelopmental condition. That isn't to say
  |that it could not be the case for some.


|u/UkuleleZenBen - 2 days
|
|It's interesting because the sleep researcher Matthew Walkers' book
|talked about how we all have different genetic "chronotypes" or times of
|day that we are more likely to base ourselves around. So that the tribe
|can have watch people at night.   Here they call it sleep disruption but
|as an adhder with a sleep difference to normal it feels like the world
|of this time is the one that's confused. Since I stopped working on
|trying to fit the mainstream narrative of sleep times I've been way more
|productive and I have energy to do a lot in those quiet hours.   As a
|side note it makes sense that distractibility would be called a "hunters
|eye" not so long ago in the grand scheme of things. We adhders are
|carrying genetics of another age. Optimized for a different age rather
|than for this blip of an age we are passing through.


  |u/DinoDude23 - 1 day
  |
  |Unfortunately that whole “Hunter vs farmer” framing doesn’t have a lot
  |of support, and I say that with great reluctance as a fellow ADHDer. 
  |Selection against adhd-associated alleles *predates* the advent of
  |Neolithic farmers in Europe; moreover, the higher the proportion of
  |Hunter-gatherer ancestry among individuals in those ancient
  |populations, the LOWER the frequency of ADHD-associated alleles among
  |those individuals.   That suggests Paleolithic Hunter-gatherer
  |populations were already experiencing selective pressures against the
  |ADHD phenotype. Any phenotype x environment mismatch would have to be
  |before anatomically modern humans appeared to begin with.   The whole
  |“hunter vs farmer” framing is also  overly simplistic, as it asserts
  |that Hunter-gathering requires less executive functioning…and I simply
  |do not believe that is the case. Planning ahead and situational
  |awareness is just as important for hunters as for farmers. A guy
  |hyperfocusing on catching a gazelle might not see the leopard stalking
  |him while he’s at it. The underlying assumption about the cognitive
  |load of one lifestyle versus the other is a massive assertion without
  |any rigorous support to my knowledge.     Variation will exist purely
  |because of mutation, drift, and gene flow. Not every allele exists
  |because of natural selection. Nor does every allele persist because of
  |it; Natural selection can’t completely purge deleterious variants if
  |the genetic load of the population is high enough. The brutal fact is
  |that there is simply diversity among humans in any given
  |population. Some of those mutations will make our lives easier, others
  |not.   


    |u/ditchdiggergirl - 1 day
    |
    |>Unfortunately the whole “Hunter vs farmer” framing doesn’t have a
    |lot of support,  Unfortunately neither does the night watchman
    |theory. In fact it can probably be ruled out. But people find
    |comfort in believing their conditions have a purpose.


      |u/NonConRon - 1 day
      |
      |Can you tell us more about that? I really like that theory. -.-


    |u/GeekYogurt - 1 day
    |
    |I mean, I could be a good pre-historic hunter but I kept putting off
    |sharpening my arrows and now I’m running out of the cave door right
    |at the end of the sabretooth migration with a few dull nubs on a
    |stick and a bow that came with an introductory DVD on how to use it
    |that I never watched.


  |u/DogOnABike - 1 day
  |
  |Whenever I've had a vacation or other scenario where I don't have to
  |plan my sleep around responsibilities, and can just go to bed when I
  |feel like it and sleep until I wake naturally, I've always settled
  |into a sleep schedule around 2-10 AM. I felt more energetic, focused,
  |and in a generally better mood, too.


  |u/tequilavixen - 1 day
  |
  |My oura ring actually tells me what my chronotype is based on my sleep
  |data and suggests my bedtime accordingly


  |u/Top_Hair_8984 - 1 day
  |
  |Was just about to add a similar post. Yes!   I'm much older so usually
  |have the luxury of sleeping when I naturally would rather than forced
  |into the 9-5 schedule.  But I had that when I was younger for sure and
  |struggled badly with it.  I'd absolutely agree that the present era
  |has no room for most people's natural cadence. We all are supposed to
  |conform.


|u/appogiatura - 1 day
|
|All I can add is that when I got a CPAP my doctor removed my ADHD
|diagnosis. In the case I still have it, symptoms are significantly more
|manageable and we were able to focus on anxiety/ocd instead and Prozac
|helped.


  |u/jonathot12 - 1 day
  |
  |thanks for sharing. i’m of the opinion that my ADHD is likely 90% due
  |to my rare form of sleep apnea (catathrenia) causing essentially long
  |term sustained mental fatigue, which of course destroys executive
  |function over time. i’m waiting on a sleep study in december, but i am
  |holding out hope that getting a CPAP will eventually lead to my
  |diagnosis being revoked too. which would be lovely.  i think people
  |often forget that these diagnoses are based on symptomology and not
  |etiology and therefore could be caused by a variety of factors likely
  |more impactful than just genes. my lack of self-discipline was another
  |factor, and since i’ve tried treating that meaningfully, my symptoms
  |have reduced. there’s more to the constellation of symptoms that make
  |up ADHD than most ‘neurology-narrow’ or ‘biological-determinist’
  |laymen want to admit.


    |u/appogiatura - 1 day
    |
    |Other thing I’ll add is if you don’t wanna wait until December,
    |Lofta has sleep tests if you don’t mind paying $200 out of pocket.
    |Get the CPAP in about a week, two tops.


      |u/jonathot12 - 1 day
      |
      |that’s nice, thanks. mine is three weeks away so i’ll probably
      |hold out but that’s good to know for if they cancel on me again
      |like they did for my august study. appreciate it!


  |u/MediocrePotato44 - 1 day
  |
  |I had a sleep study done because unless I get 11-12 hours of sleep a
  |night, I’m exhausted. 7-8 houses might as well be 4. They were so sure
  |it was sleep apnea and not messed up sleep stages but nope, they were
  |wrong. A whole lot of money wasted for an uncomfortable night of sleep
  |and a prescription that at least helps get me to sleep but doesn’t
  |help me require less sleep. I live chronically exhausted because I
  |can’t sleep as much as I need to. 


    |u/Archinatic - 1 day
    |
    |Did they check for RDI/consider UARS? There is so much wrong with
    |how sleep disordered breathing is diagnosed even when they say you
    |don't have it you might very well still have it.


|u/cat-cash - 1 day
|
|I firmly believe that if I didn’t have insomnia, I wouldn’t have ADHD.
|It’s not even the lack of sleep, but I feel like the part of my brain
|that is responsible for sleep is just broken.    Like, even if sleeping
|pills worked for me, it wouldn’t matter because it wouldn’t fix the
|underlying issue and that issue is also the one that makes me a spaz.


|u/starion832000 - 1 day
|
|As as adult with ADHD and severe insomnia I have always wondered what
|the connection was. It's not just that I don't get sleepy... Ever.. I
|also don't get tired or fatigued. I have absolutely endless energy when
|I want to.   I'm 45 but there's no amount of heavy labor that makes my
|body tired. I'm not claiming to be in good shape.. no. I'm just saying
|that what makes a normal person eventually slow down just doesn't happen
|to me.   It sounds great, but honestly I just want to fall asleep.


  |u/TableTopFarmer - 1 day
  |
  |I have a 15;00 sleep aid device that looks like a watch. It uses
  |pulsed emissions to trigger the natural release of melatonin. It works
  |well. Walmart carries them but ther are more expensive devices on
  |Amazon


    |u/NonConRon - 1 day
    |
    |Huh? Pulses you say? Tell us more.


|u/mthlmw - 1 day
|
|That's really interesting! My psych suggested I take 5-HTP before bed
|for sleep issues (after starting atomoxetine), since it's a precursor to
|serotonin and might increase my energy in the morning. Looks like
|serotonin is **also** a precursor to melatonin, so I'm taking a
|supplement for that too!


  |u/5ftpinky - 1 day
  |
  |This is so interesting. I've never heard of 5-HTP but I'm tempted to
  |try it.   >Looks like serotonin is also a precursor to melatonin, so
  |I'm taking a supplement for that too!  Do you mean that you're also
  |taking melatonin?  It continues to amaze me everytime i learn about
  |the body's interconnectedness. It's never just one thing.


    |u/mthlmw - 1 day
    |
    |No, just the 5-HTP, but I never realized the one thing turned into
    |multiple others haha.


|u/321gogo - 1 day
|
|This makes a lot of sense for me. The “tired”feeling I get when I take
|melatonin is really something I almost never feel without it.


  |u/iamDa3dalus - 1 day
  |
  |Melatonin makes it so hard for me to wake up. Even a tiny amount. Like
  |lead.


|u/FroggyCrossing - 1 day
|
|I'm pale and have ADHD someone ELI5 for me please  Edit: Im now reading
|it's melatonin and not melanin...


|u/StrawberryKiss2559 - 1 day
|
|Is this why I’ve always been a night owl?


|u/U_Kitten_Me - 2 days
|
|Hm, interesting. I have ADHD and always suspected I might have some kind
|of genetic issue with melatonin, because I - as well as my father and
|grandmother - have always had seasonal depression.


  |u/zorionora - 1 day
  |
  |Hi, same. Could you elaborate on link between melatonin and seasonal
  |depression ?


    |u/U_Kitten_Me - 1 day
    |
    |Hey fellow winter blueser. I haven't looked into this stuff for a
    |few years but from what I remember, seasonal depression is strongly
    |linked to melatonin. I guess back in prehistoric times this was
    |supposed to signal us to go into it caves and go into low energy
    |consumption mode or something.  Some of us today just have this more
    |than others (well, and more melatonin) and have to pull through the
    |season while our energy is holding us back all the time... This is
    |also why therapy lamps help a lot of people with seasonal
    |depression: They reduce the melatonin. (Didn't seem to help me for
    |whatever reason, though). You may want to read up on agomelatine.
    |Sounds promising. Good luck!


      |u/zorionora - 1 day
      |
      |Thank you for responding. It feels like some missing puzzle pieces
      |are coming together, possibly. Will look into agomelatine.


|u/accordyceps - 1 day
|
|I don’t have ADHD but autism, and also had insomnia as a young child
|(would stare at the ceiling for hours after being put to bed) and into
|adulthood.  I wonder if there are any links to autism and melatonin
|regulation, as well.  Looks like it:
|https://scholar.google.com/scholar_lookup?title=The+serotonin-N-acetylse
|rotonin–melatonin+pathway+as+a+biomarker+for+autism+spectrum+disorders&a
|uthor=Pagan,+C.&author=Delorme,+R.&author=Callebert,+J.&author=Goubran-B
|otros,+H.&author=Amsellem,+F.&author=Drouot,+X.&author=Boudebesse,+C.&au
|thor=Le+Dudal,+K.&author=Ngo-Nguyen,+N.&author=Laouamri,+H.&publication_
|year=2014&journal=Transl.+Psychiatry&volume=4&pages=479&doi=10.1038/tp.2
|014.120&pmid=25386956#d=gs_qabs&t=1731747774430&u=%23p%3DcvUgh-HeIloJ


|u/nomad1128 - 1 day
|
|I try testing out if I'm telepathic at night. If any of you have been
|telepathically Karate Kid Kicked randomly while you're falling asleep,
|it was me. You're welcome, and thank you for helping me fall asleep.


|u/HairyNutsack69 - 1 day
|
|I feel like we been knowing